Personal Info.

Full Name

Current position

Marwa Hamdy Hassan Tolba.

Associate Professor of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Egypt.

Education

02/2015 –

03/2018

PhD in Pharmaceutical  Sciences (Medicinal Chemistry Department), Faculty of Pharmacy, Zagazig University

09/ 2010 –

06/2014

Master's Degree in Pharmaceutical Sciences (Medicinal Chemistry Department), Faculty of Pharmacy, Zagazig University

08/2004 –

08/2009

Bachelor's Degree in Pharmaceutical Sciences, Faculty of Pharmacy, Zagazig University.

Research Interests

- Design, and synthesize new anti-influenza agents to overcome the developed drug resistance toward existing drugs.

- The syntheses of a series of novel drugs evaluated against an RNA viral panel, and with moderate activity against the hepatitis C virus, Zika virus, and human respiratory syncytial virus.

- Instrumental analytical techniques such as chromatography, spectroscopy, and mass spectrometry help identify and quantify the presence of antibiotics in samples and pharmaceutical dosage forms.

- Using HPLC techniques to study the stability of the drugs

- Isocratic HPLC methods for quantitatively determining some drugs such as cinnarizine, methocarbamol, and paracetamol

- Quantitative proton nuclear magnetic resonance spectroscopy (1H-qNMR) was used to quantify piracetam in pharmaceuticals, molnupiravir, favipiravir, and zinc gluconate

- The implementation of analytical quality by design concepts for the optimization of drug analysis

- Using ultrasound-assisted dispersive micro solid-phase extraction by applying unprecedented adsorbent-modified multiwalled carbon nanotubes for preconcentration and separation of trace cobalt (Co(II)) and nickel (Ni(II)) ions in diverse ecological samples before determination by flame atomic absorption spectrometry

Publications : https://scholar.google.com/citations?user=gxPQm1IAAAAJ&hl=en

1.  Mousa, H. S., Gouda, A. A., El-Zahry, M. R., ElHosary, M. M. I., & Hassan, M. H. (2025). Greenness-integrated analytical quality by design-compliant development of a quasi-HDES-DLLME method for patent blue V preconcentration from various food products, and environmental water samples. Microchemical Journal, 113052.                                                                                                         

https://doi.org/10.1016/j.microc.2025.113052

2. Hassan, M. H., Abou-Elkhair, R. A., Hassan, A. E., & Mousa, H. S. (2025). Analytical quality by design-compliant development of quantitative 1H-and 19F-nuclear magnetic resonance methods for the analytical evaluation of the anti-cancer drug, sorafenib. Microchemical Journal, 208, 112544. https://doi.org/10.1016/j.microc.2024.112544

3- Marwa H. Hasan, Ayman A. Gouda, Abdalla E.A. Hassan, Shaimaa G. Elsayed, Heba Salah Mousa. (2024). Implementation of analytical quality by design concepts for the optimization of quantitative 1H nuclear magnetic resonance (1H-qNMR) method for quantitation of novel anti-covid drugs (molnupiravir and favipiravir) in their pharmaceutical dosage forms.  Microchemical Journal 196 (2024) 109582. https://doi.org/10.1016/j.microc.2023.109582.

4- Abdalla E. A. Hassan, Hend A. Hegazy, Islam Zaki, Marwa H. Hassan, Medhat Ramadan, Abdelfattah Z. Haikal, Jia Sheng, Reham A. I. Abou-Elkhair. (2023) Design, synthesis, and evaluation of 4′‐phosphonomethoxy pyrimidine ribonucleosides as potential anti‐influenza agents. Archiv der Pharmazie 2200382. DOI:  10.1002/ardp.202200382

5- Hasan, Marwa Hamdy. "Spectrophotometric Investigations of Some Non-steroidal anti-inflammatory drugs (NSAIDs): A Brief Review." Octahedron Drug Research (2023).

6- Hassan MH, Hassan AEA. (2022) Quantitative 1HNMR Spectroscopy: Analysis of Zinc Gluconate in Utozinc® Tablets, a Mixture of Zinc Gluconate and Vitamin C. J AOAC Int. 22;106(1):34-39. doi: 10.1093/jaoacint/qsac127.

7- A. A. Gouda, R. El Sheikh, H. M. El Sayed, A. M. Khedr, Sh. Abo Al Ezz, W. Gamil & M. Hamdy (2022). Ultrasound-Assisted Dispersive Microsolid-Phase Extraction for Preconcentration of Trace Cobalt and Nickel in Environmental Samples Prior to their Determination by Flame Atomic Absorption Spectrometry. J Appl Spectrosc 89, 567–578. https://doi.org/10.1007/s10812-022-01396-4

8- Marwa H. Hasan, Mohamed E. El-sadek & Sobhy M. El-Adl (2021) The Using of Dansyl Chloride for Novel Spectrofluorimetric Determination of Paracetamol in Tablet Dosage Form, Analytical Chemistry Letters, 11:3, 427-436.

9- Abou-Elkhair RAI, Du J, Wasfy AA, Khaill NA, Maaroof HM, Hassan MH, Ahmed AS, Hassan AEA, Sheng J. (2021) Synthesis of 6-Aza-2-Hydroxyimino-5-Methylpyrimidine Nucleosides for Antiviral Evaluation. Curr Protoc. (12):329. 

10- El-Adl SM, El-Sadek ME, Hasan MH . (2019) . Spectrophotometric Analysis of Azithromycin and Clarithromycin in Tablets and Human Plasma Using p-Chloroanilic Acid. Analytical Chemistry Letters. 362-372.

11- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan (2017). Determination and Validation of  Piracetam in Pharmaceuticals Using Quantitative Nuclear Magnetic Resonance Spectroscopy.  Analytical Chemistry Letters. 271-279.

12- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan .(2017). Design and Validation of  Stability Indicating Assay of  Glibenclamide Using RP-HPLC Technique in Both Bulk, Pharmaceutical Formulations and Human Plasma. J Appl Pharm. 250-255. 

13-  El-Adl SM, El-Sadek ME, Hasan MH . (2016) . Exploring Novel Isocractic HPLC Method for Quantitative Determination of  Cinnarizine and Piracetam in Their Capsule Preparations. J App Pharm. 225-230.

14- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan (2016) HPLC Method for Determination of  Methocarbamol and Paracetamol in Their Pharmaceutical Formulation. Analytical Chemistry Letters, 6:5, 622-630.

15- El-Adl SM, El-Sadek ME, Hasan MH . (2016) . Exploring Novel Isocractic HPLC Method for Quantitative Determination of  Cinnarizine and Piracetam in Their Capsule Preparations. J App Pharm. 225-230.

16- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan. (2014). Extractive Spectro Estimation of Clarithromycin and Clindamycin in Bulk and Dosage Forms. Asian J. Res. Pharm. Sci. 186-179.

17- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan. (2014). Spectrophotometric Investigations on Cephalosporines by Ellman's Reagent in Bulk and Dosage Forms. Asian J. Res. Pharm. Sci. 196-201

18- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan. (2014). HPLC Determination of  Two Cephalosporines with one Macrolide in Bulk and Dosage Forms. International Journal of Technology . 180-185

19- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan. (2014). HPLC Determination of Cefepime, Cefotaxime and Cefoperazone in Bulk and Dosage Forms. Asian J. Pharm. Ana. 168-173.

20- Sobhy M. El-Adl, Mohamed E. El-sadek & Marwa H. Hasan. (2014). Bromometric Estimation of  Cefixime, Clarithromycin and Clindamycin in Bulk and Dosage Forms. Asian J. Pharm. Ana. 137-146.