Staff

سمر على محمد محمد القليوبى

سمر على محمد محمد القليوبى

سمر على محمد محمد القليوبى


S.elKalyoubi@pharm.psu.edu.eg


كلية الصيدلة ببورسعيد



أستاذ


Faculty of pharmacy, Port Said University


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Biography

Current Position

Professor of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Egypt

Educational Background

B.Sc. in Pharmacy, Zagazig University, 1990 – Very Good with Honors

M.Sc. in Medicinal Chemistry, Zagazig University (2005, in collaboration with Konstanz University, Germany)

Ph.D. in Pharmaceutical Organic Chemistry, Al-Azhar University, 2010

Academic and Supervisory Experience

Teaching experience in Pharmaceutical Organic Chemistry for undergraduate and postgraduate students.

Supervisor and examiner for numerous M.Sc. and Ph.D. theses.

Co-author of the Department of Pharmaceutical Organic Chemistry handbooks.

International Experience & Academic Roles

Researcher, Konstanz University, Germany.

Researcher, Okayama University, Japan.

Head, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Egypt.

Head, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Egypt.

General Coordinator, Medical Colleges Programs, Jazan University, Saudi Arabia.

Academic Manager, PharmD-Clinical Pharmacy Program, East Port Said National University (one year).

Research Interests & Publications

Author of multiple international publications in synthesis, drug design, anticancer, antimicrobial, and antiviral agents.

Publications

  1. The Yoneda – Reaction; Taghavi-Moghadam S., El-Kalyoubi S., Pfleiderer W., Pteridines, (1997) 8, 50.
  2. Synthesis, DNA Binding and Antiviral Activity of New Uracil, Xanthine, and Pteridine Derivatives; El-Sabbagh O.I., El-Sadek M.E., El-Kalyoubi S. and Ismail I., Arch Pharm. Chem. Life Sci, (2007) 340, 26.
  3. Synthesis, DNA binding studies of new pyrimidothiazepine and pyrimidobenzothiazepine derivatives; Bothaina A. Mousa, Ashraf H. Bayoumi, Makarem M. Korraa, Mohamed G. Assy, and Samar A. El-kalyoubi, AFINDAD LXIX, (2012) 558, 144.
  4. One pot Synthesis, DNA binding and fragmentation in vitro of new fused uracil derivatives for anticancer properties; Bothaina A. Mousa, Ashraf H. Bayoumi, Makarem M. Korraa, Mohamed G. Assy and Samar A. El-kalyoubi, AFINDAD LXIX, (2012) 559, 224.
  5. A novel one-pot and efficient procedure for synthesis of new fused uracil derivatives for DNA binding, Bothaina A. Mousa, Ashraf H. Bayoumi, Makarem M. Korraa, Mohamed G. Assy and Samar A. El-kalyoubi, International Journal of Organic Chemistry, (2015) 5, 37.
  6. Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity,  Samar El-kalyoubi , Fatmah Agili  and Shaker Youssif; Molecules, (2015) 20 (10), 19263.
  7. Synthesis and evaluation of antitumor activities of novel fused tri- and tetracyclic uracil derivatives, Samar El-Kalyoubi and Eman Fayed, Journal of  Chemical Research , (2016) 40, 771–777.
  8. A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution, Samar El-Kalyoubi and Fatimah Agili, Molecules, (2016) 21, 1714
  9. One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthenes, Samar A. El‑Kalyoubi, Eman A. Fayed and Ahmed S. Abdel‑Razik, Chemistry Central Journal, (2017) 11, 66.
  10. Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent, Samar A. El-Kalyoubi, Chemistry Central Journal, (2018) 12, 64.
  11. Synthesis, Characterization and Antimicrobial Activities of Some 5-Bromouracil-Metal Ion Complexes; Said M. Teleb , Muhammad E. Askar, Samar A. El-Kalyoubi and Akmal S. Gaballa; Bull. Chem. Soc. Ethiop., (2019) 33(2), 255-268.
  12. Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives; Samar El-Kalyoubi and Fatimah Agili; Molecules, (2020) 25, 5205.
  13. Review on the significance of quinazoline derivatives as broad spectrum anti-cancer agents; Reda R. Mabrouk, Mohamed Ayman El-Zahabi, Samar A. El-Kalyoubi, Hazem A. Mahdy and Abdallah E. Abdallah; Az. J. Pharm Sci., Vol. 64 (2021).
  14. Synthesis, In Silico Prediction and In Vitro Evaluation of Antimicrobial Activity, DFT Calculation and Theoretical Investigation of Novel Xanthines and Uracil Containing Imidazolone Derivatives; by Samar El-Kalyoubi, Fatimah Agili ,Wael A. Zordok and Ashraf S. A. El-Sayed; Int. J. Mol. Sci., (2021) 22, 10979.
  15. Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives; M. A. Mohamed, R. R. Khattab, A. A. F. Wasfy, M. A. Abo-Riya, S. El-Kalyoubi and N. A. Hassan; Russian Journal of Bioorganic Chemistry,  47, 1312 (2021).
  16. Novel uracil derivatives depicted potential anticancer agents: In Vitro, molecular docking, and ADME study; Samar El-Kalyoubi, Fatimah Agili, Islam Adel, Mohamed A. Tantawy, Arabian journal of Chemistry, (2021)15, 103669.
  17. Synthesis, Molecular Docking and Anticancer Activity of Some 5-Aryl-5,10-dihydropyrido[2,3-d:6,5-d′]dipyrimidine-2,4,6,8-tetraone Derivatives and Pyrido[2,3-d]pyrimidines; Basant Farag, Fatimah Agili, Samar El-Kalyoubi, Said A. Said, Shaker Youssif and Wael Shehta; ChemistrySelect, (2022)7,  e202103834, 1.
  18. In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors; Eman A. Fayed, Eman S. Nosseir, Ahmed Atef and Samar A. El‑Kalyoubi; Molecular Diversity, (2022)26,  341.
  19. One-Pot Synthesis and Molecular Modeling Studies of New Bioactive Spiro-Oxindoles Based on Uracil Derivatives as SARS-CoV-2 Inhibitors Targeting RNA Polymerase and Spike Glycoprotein; Samar A. El-Kalyoubi, Ahmed Ragab, Ola A. Abu Ali, Yousry A. Ammar, Mohamed G. Seadawy, Aya Ahmed and Eman A. Fayed; Pharmaceuticals, (2022)15, 376.
  20. Uracil as a Zn-Binding Bioisostere of the AllergicBenzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors; Samar A. El-Kalyoubi, Ehab S. Taher, Tarek S. Ibrahim, Mohammed Farrag El-Behairy, and Amany M. M. Al-Mahmoudy, Pharmaceuticals, (2022) 15, 494.
  21. Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies. Wael Shehta; Fatimah Agili; Basant Farag; Said A Said; Shaker Youssif; Mohamed E Abdraboh; Samar El-Kalyoubi, Future Medicinal Chemistry, (2023). DOI: 10.4155/fmc-2022-0279
  22. Synthesis and in vitro study of pyrimidine–phthalimide hybrids as VEGFR2 inhibitors with antiproliferative activity, Wael Shehta; Fatimah Agili; Basant Farag; Shaker Youssif; Samar J Almehmadi; Sherin M Elfeky; Samar El-Kalyoubi, Future Medicinal Chemistry, (2023). DOI: 10.4155/fmc-2023-0025.
  23. Synthesis, pharmacological evaluation, DFT calculation, and theoretical investigation of Spirocyclohexane derivatives,  Atef M. Abdel Hamid, Asmaa H.Amer, Mohammed G. Assy, Wael A. Zordok, Samar M Mouneir, Samar Elkalyoubi, Wesam Shehab, Bioorganic Chemistry, (2023) 131, 106280. DOI: 10.1016/j.bioorg.2022.106280.
  24. Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors, Samar El-Kalyoubi; Samiha A. El-Sebaey; A. M. Rashad; Hanan A. AL-Ghulikah; Mostafa M. Ghorab; Sherin M. Elfeky, Journal of Enzyme Inhibition and Medicinal Chemistry, (2023) 38, 2198163. DOI: 10.1080/14756366.2023.2198163.
  25. Design and synthesis of uracil/thiouracil based quinoline scaffolds as topoisomerases I/II inhibitors for chemotherapy: A new hybrid navigator with DFT calculation, Samar Elkalyoubi, Samar S. Elbaramawi, Wael A. Zordok, Azizah Malebari, Martin Safo, Tarek S Ibrahim, Ehab Taher Bioorganic Chemistry, (2023) 136, 106560. DOI:10.1016/j.bioorg.2023.106560.
  26. Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E, Samar A. El-Kalyoubi; Hesham A. M. Gomaa; Elshimaa M. N. Abdelhafez; Mohamed Ramadan; Fatimah Agili; Bahaa G. M. Youssif, Pharmaceuticals, (2023) 8;16(5):716.  DOI: 10.3390/ph16050716.
  27. Design and synthesis of novel uracil-linked Schiff bases as dual histone deacetylase type II/topoisomerase type I inhibitors with apoptotic potential, Samar El-Kalyoubi; Samar S Elbaramawi; Ahmed G Eissa; Essam Al-Ageeli; Yahya Hasan Hobani; Aya Ali El-Sharkawy; Hossam Taha Mohamed; Ahmed A Al, Karmalawy; Hamada S Abulkhair, Future Medicinal Chemistry, (2023). DOI: 10.4155/fmc-2023-0112.
  28. Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling, Samar El-Kalyoubi; Samiha A. El-Sebaey; Ahmed A. El-Sayed; Moustafa S. Abdelhamid; Fatimah Agili; Sherin M. Elfeky, Journal of Enzyme Inhibition and Medicinal Chemistry, (2023)  38, 2232125. DOI: 10.1080/14756366.2023.2232125.
  29. Discovery of New Uracil and Thiouracil Derivatives as Potential HDAC Inhibitors, Omnia R. Elbatrawy; Mohamed Hagras; Moshira A. El Deeb; Fatimah Agili; Maghawry Hegazy; Ahmed A. El-Husseiny; Mahmoud Mohamed Mokhtar; Samy Y. Elkhawaga; Ibrahim H. Eissa; Samar El-Kalyoubi, Pharmaceuticals, (2023). DOI: 10.3390/ph16070966.
  30. New thiouracil derivatives as histone deacetylase inhibitors and apoptosis inducers: design, Synthesis and anticancer evaluation, Omnia R Elbatrawy, Moshira A El Deeb, Mohamed Hagras, Fatimah Agili, Maghawry Hegazy, Ahmed A El-Husseiny, Mohamed A Elkady, Ibrahim H Eissa, Samar El-Kalyoubi,  Future Medicinal Chemistry, (2023). https://doi.org/10.4155/fmc-2023-0106
  31. Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs, Reda R. Mabrouk, Abdallah E. Abdallaha, Hazem A. Mahdy, Samar A. El-Kalyoubi, Omar Jamal Kamal, Tamer M. Abdelghany, Mohamed F. Zayed, Heba K. Alshaeri, Moudi M. Alasmari and Mohamed Ayman El-Zahabi, Int. J. Mol. Sci. (2023), 24, 12416; https://doi.org/10.3390/ijms241512416.
  32. Design and Synthesis of New Spirooxindole Candidates and their Selenium Nanoparticles as Potential Dual Topo I/II Inhibitors, DNA Intercalators, and Apoptotic Inducers, Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee, Ahmed A. Al-Karmalawy Journal of Enzyme Inhibition and Medicinal Chemistry, (2023), 38, 2242714; https://doi.org/10.1080/14756366.2023.2242714.
  33. Novel Aminopyrimidine-2, 4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies, Samar El-Kalyoubi, Samiha A El-Sebaey, Sherin M Elfeky, Hanan A Al-Ghulikah, Mona S El-Zoghbi, Pharmaceuticals, (2023), 16 (9), 1303; https://doi.org/10.3390/ph16091303.
  34. Synthesis, In-Vitro, In-Vivo Screening, and Molecular Docking of Disubstituted Aminothiazole Derivatives and Their Selenium Nanoparticles As Potential Antiparkinson Agents, Lamiaa O El-Halaby, Nada F Abo El-Magd, Samar J Almehmadi, Ahmed A El-Sayed, Samar El-Kalyoubi, Sherin M Elfeky, Journal of Molecular Structure, (2024), 1315, 138951; https://doi.org/10.1016/j.molstruc.2024.138951
  35. Comprehensive, Characterization and Molecular Docking of Novel 1, 4-Diaryl/Alkyl Substituted Diazine Analogues for Antimicrobial Application, Marwa M Rezk, AAF Wasfy, Mohamed S Behalo, Samar El-Kalyoubi, Aly A Aly, Egyptian Journal of Chemistry, (2025), Articles in Press; DOI: 10.21608/ejchem.2025.377743.11637.
  36. Synthesis, Antimicrobial Activity and Molecular Docking of Novel Series of Phthalazine Derivatives, Marwa M Rezk, AAF Wasfy, Mohamed S Behalo, Samar El-Kalyoubi, Aly A Aly, Egyptian Journal of Chemistry, (2025), Articles in Press; DOI:  10.21608/ejchem.2025.361774.11447.
  37. Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents, Wael Shehta, Norah A. Alsaiari, Basant Farag, Marwa M. Abdel-Aziz, Shaker Youssif, Sherin M Elfeky, Samar El-Kalyoubi, Nermine A. Osman, SynOpen, (2025), 9, 73–83; DOI: 10.1055/s-0043-1775424.
  38. Synthesis and radiolabelled evaluation of novel pyrimidine derivatives as dual α-amylase inhibitors and GIT-targeted molecular imaging probe, Doaa A. Elsayed, Wael Shehta, S. El-Kalyoubi, Adli Selim, Mohammed G. Assy, Omar Metwally, Ahmed A. Al-Kubaisi, Sameer A. Awad and F. Marzook, RSC Adv., (2025), 15, 29544-29559;  DOI: 10.1039/D5RA04955E.

 

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