Biography

I am an Associate Professor of Medicinal Chemistry at the Faculty of Pharmacy, Port Said University. My research focuses on drug discovery and design using computational, in vitro, and in vivo approaches, with extensive experience in academic teaching and supervision. I have contributed to internationally published research and is passionate about bridging scientific research with practical applications in drug development.

Educational Qualification

B.Sc (Faculty of pharmacy Cairo university), Excellent with honor

MD  (Faculty of pharmacy Cairo university)

PhD  (Faculty of pharmacy Cairo university)

Academic And Professional Experience

Teaching assistant (Faculty of pharmacy Cairo university)

Research assistant (NODCAR)

Assistant lecturer (Faculty of pharmacy Port Said university)

Lecturer (Faculty of pharmacy Port Said university)

Associate professor (Faculty of pharmacy Port Said university)

Admin of “Thinqi“ website for electronic education, at Faculty of Pharmacy, Port Said University.

A Member of the executive team for “Strategic Planning”, Port Said University (2023-2027).

Publications

• “Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment”, Biorganic Chemistry, 2025

  Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies, RSC Medicinal Chemistry, 2025

  Novel inhibitors of oncogenic Wnt/TCF-4/β catenin signaling pathway: Design, synthesis, molecular docking studies and apoptosis inducing activity of pyrimidothiazino dihydropyrimidotriazepino- and1,3,4-thiadiazolopyrimido-indole hybrids, Bioorganic Chemistry, 2025

  Design and synthesis of novel substituted s-triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments, Archiv Der Pharmazie, 2025

  Exploring the anticancer potential of new pyrazolopyrimidine analogues as multi-target directed EGFR/STAT3 downregulatory candidates with apoptotic potential, New Journal of Chemistry, 2025

  Targeted synthesis of a trimethoxy phenyltetrahydropyrimidine analogue designed as a DNA intercalator: in silico, multispectroscopic, thermodynamic, and in vitro approaches, RSC Advances, 2025

• “Design and Synthesis of Novel Pyrazolopyrimidine Candidates as Promising EGFR-T790M Inhibitors and Apoptotic Inducers”, Future medicinal chemistry, 2024.
• “Multi-Target Rational Design and Synthesis of Novel Diphenyl-Tethered Pyrazolopyrimidines Targeting EGFR and Topoisomerase II with Potential DNA Intercalation and Apoptosis Induction”, Bioorganic chemistry, 2024.
• “Experimental design of D-α-tocopherol polyethylene glycol 1000 succinate stabilized bile salt based Nano-vesicles for improved cytotoxicity and bioavailability of colchicine binding site inhibitor Candidates: In Vitro, in silico, and pharmacokinetic studies” International journal of pharmaceutics, 2024.
• “Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity”, Journal of enzyme inhibition and medicinal chemistry, 2024.
• “Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors” ACS omega, 2024.

• “Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in virto assessments with structure-activity relationship.” Journal of biomolecular structure and dynamics, 2024.
• “Partnering essential oils with antibiotics: proven therapies against bovine Staphylococcus aureus mastitis.” Frontiers in cellular anf infection microbiology, 2024.

• “Harnessing molecular hybridization approach to discover novel quinoline EGFR-TK inhibitors for cancer treatment” Future medicinal chemistry, 2024.
• “Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment” Drug development research, 2024.

• “Pharmacophore‐based, rationale design, and efficient  synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators” Archiv der Pharmazie, 2024.
• Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancer via P53,BAX, caspases-3, 6, 8, 9, BCL-2, MMP2, and MMP9 modulations” RSC advances, 2024.

•  “Tamarindus indica Extract as a Promising Antimicrobial and Antivirulence Therapy”, Antibiotics, 2023.
• “Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations”, Journal of Medicinal chemistry, 2023.
• “Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies”, Journal of enzyme inhibition and Medicinal Chemistry, 2023.
• “Phytochemical Characterization of Pterocephalus frutescens with In-Silico Evaluation as Chemotherapeutic Medicine and Oral Pharmacokinetics Prediction Study”, Scientia Pharmaceutica, 2023.
• “Bioanalytical LC–MS/MS method for simultaneous estimation of atorvastatin, its major active metabolites and ezetimibe”, Bioanalysis, 2022.
• “A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval”, Drug Design, Development, and Therapy, 2022.
• “Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies”, Journal of enzyme inhibition and Medicinal Chemistry, 2022.
• “Design, Synthesis, Biological Evaluation, and SAR Studies of Novel Cyclopentaquinoline Derivatives as DNA Intercalators, Topoisomerase II Inhibitors, and Apoptotic Inducers”, New Journal of Chemistry, 2022.
• “Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies”, Bioorganic Chemistry, 2022.
• “Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease”, Journal of enzyme inhibition and Medicinal Chemistry, 2022.
• “Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro, In-vivo, In-silico and SAR studies”, Bioorganic Chemistry, 2022.
• “Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies”, International Journal of Molecular Sciences, 2022.
• “Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors”, Journal of enzyme inhibition and Medicinal Chemistry, 2022.
• “Analysis of the ternary antiretroviral therapy dolutegravir, lamivudine and abacavir using UV spectrophotometry and chemometric tools”, Spectrochimica acta part A, 2022.
• “β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization”, RSC Advances, 2021.
• “Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview” Vaccines, 2021.
• “In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR‑2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity”, ACS Omega, 2021.
• “In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus”, Computer in biology and medicine, 2021.
•  “In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins”, Journal of Biomolecular Structure and Dynamic, 2021.
• “Determination of six drugs used for treatment of common cold by micellar liquid chromatography”, analytical and bioanalytical chemistry, 2021.
• “Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization”, Molecules, 2021.
• “Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: theoretical study”, RSC Advances, 2021.
• “Synthesis, Isolation and Characterization of three acid and alkaline hydrolytic products of Nimodipine and Development of a valid RP-HPLC method for simultaneous determination of Nimodipine and Citicoline sodium in the presence of Nimodipine degradation products in Bulk and Tablets” Brazilian journal of analytical chemistry, 2021.
• “Development and Validation of RP-HPLC Method for Simultaneous Estimation of Tiotropium Bromide, Formoterol Fumarate, and Olodaterol HCl in Bulk and Metered Dose Aerosols: Application to Olodaterol HCl Forced Degradation Study and Degradation Kinetics”, Chromatographia, 2017.
• “Stability Indicating HPLC-UV vs. UPLC-DAD for Estimation of Atorvastatin Simultaneously with Aspirin, Clopidogrel and their Related Impurities in Bulk and Capsules”, Analytical Chemistry Letters, 2017.
• “Stability Indicating RP-HPLC Method for Simultaneous Determination of Bambuterol HCl and Na Benzoate in the Presence of Bambuterol HCl Alkaline Degradation Product in Bulk and Syrups: Application to Degradation Kinetics”, Analytical Chemistry Letters, 2017.
• “HPLC-UV vs. UPLC-DAD for Estimation of Tinidazole, Benzyl Alcohol and Hydrocortisone Acetate Simultaneously with Tioconazole and Its Related Impurities in Bulk and Pharmaceutical Formulations”, Analytical Chemistry Letters, 2017.
• “A comparative study of HPLC-UV and UPLC-DAD methods for simultaneous estimation of aspirin and cilostazol in the presence of their related impurities in bulk and capsules”, Journal of Liquid Chromatography & Related Technologies, 2017.
• “Development and Validation of an RP-HPLC Method for the Determination of Vinpocetine and Folic Acid in the Presence of a Vinpocetine Alkaline Degradation Product in Bulk and in Capsule Form”, Journal of AOAC international, 2017.
• “Simultaneous Estimation of Terconazole and Benzoic Acid in Bulk and Creams Using RP-HPLC, Derivative Spectrophotometry and Chemometric Techniques”, Journal of Chemical and Pharmaceutical Research, 2017.
• “Simultaneous HPLC and derivative spectrophotometry determination of tioconazole and benzyl alcohol in bulk and cream with tioconazole forced degradation study” Analytical Chemistry: An Indian Journal, 2014.
• “Simultaneous determination of miconazole and hydrocortisone or mometasone using reversed phase liquid chromatography”, European Journal of Chemistry, 2012.