Biography

01/06/2016–30/8/2018 M.sc in Biochemistry
Faculty of science, Port Said (Egypt)
Thesis title Study of Antitumor Effect of Some Medicinal Plants With Selenium Nanoparticles
09/09/2019–30/1/2022 PhD in Biochemistry
Thesis title Renoprotective Effect of Diacerein and Zinc Oxide Nanoparticles in Kidney Injury Induced by Cisplatin

Educational Qualification

04/01/2016–21/05/2019 Demonstrator at Chemistry Department (Biochemistry Division), Faculty of science, Port Said University, Egypt
22/05/2019– 30/1/2022 Assistant Lecturer at Chemistry Department (Biochemistry Division), Faculty of science, Port Said University, Egypt
31/1/2022– Present Lecturer at Chemistry Department (Biochemistry Division), Faculty of science, Port Said University, Egypt

Academic And Professional Experience

    منسق برنامج الكيمياء الحيوية و الميكروبيولوجي بكلية العلوم جامعة بورسعيد سابقا

مدير برنامج كلية العلوم الصحية التطبيقية بجامعة شرق بورسعيد الأهلية

Publications

1) Ahmed, N. H., El-Batal, A. I., Barakat, L. A., & Khirallah, S. M. (2019).
Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra
Extract and - Irradiation to Suppress the Growth of Murine Tumor. Journal of
Advance Research in Pharmacy & Biological Science, 5(2), 01–10.
https://doi.org/10.53555/nnpbs.v5i2.693
2) El-Batal, A., Ahmed, N., Barakat, L. A. A., & Khirallah, S. (2019). Tumoricidal
Effect of Trigonella foenum-graceum Extract and Selenium Nanoparticles on
Ehrlich Carcinoma Bearing Mice. Asian Journal of Research in Biochemistry, 4(1),
1-16. https://doi.org/10.9734/ajrb/2019/v4i130059
3) Barakat LAA, Barakat N, Zakaria MM, Khirallah SM. Protective role of zinc
oxide nanoparticles in kidney injury induced by cisplatin in rats. Life Sci. 2020
Dec 1; 262:118503. doi: 10.1016/j.lfs.2020.118503. Epub 2020 Sep 29. PMID:
33007311.

4) Barakat N, Barakat LAA, Zakaria MM, Khirallah SM. Diacerein ameliorates
kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and
Bax down-regulation. Saudi J Biol Sci. 2021 Dec; 28(12):7219-7226. doi:
10.1016/j.sjbs.2021.08.025. Epub 2021 Aug 13. PMID: 34867025; PMCID:
PMC8626266.
5) Awadalla A, Abol-Enein H, Hamam ET, Ahmed AE, Khirallah SM, El-Assmy
A, Mostafa SA, Babalghith AO, Ali M, Abdel-Rahim M, Shokeir AA, Harraz
AM. Identification of Epigenetic Interactions between miRNA and Gene
Expression as Potential Prognostic Markers in Bladder Cancer. Genes (Basel).
2022 Sep 10; 13(9):1629. doi: 10.3390/genes13091629. PMID: 36140796;
PMCID: PMC9498328.
6) Khirallah SM, Ramadan HMM, Shawky A, Qahl SH, Baty RS, Alqadri N,
Alsuhaibani AM, Jaremko M, Emwas AH, Saied EM. Development of Novel 1,3-
Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory
Activity; In Vitro and In Silico Assessments. Molecules. 2022 Sep 23;
27(19):6271. doi: 10.3390/molecules27196271. PMID: 36234810; PMCID:
PMC9573447.

7) Awadalla A, Hamam ET, El-Senduny FF, Omar NM, Mahdi MR, Barakat N,
Ammar OA, Hussein AM, Shokeir AA, Khirallah SM. Zinc oxide nanoparticles
Salma Moustafa Moustafa Ahmed Khirallah
Page 4 / 5
and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin
pathway in adenine-induced nephrotoxicity in rats. Redox Rep. 2022
Dec;27(1):249-258. doi: 10.1080/13510002.2022.2139947. PMID: 36342062;
PMCID: PMC9648381.
8) Khirallah SM, Ramadan HMM, Aladl HAA, Ayaz NO, Kurdi LAF, Jaremko
M, Alshawwa SZ, Saied EM. Antidiabetic Potential of Novel 1,3,5-Trisubstituted-
2-Thioxoimidazloidin-4-One Analogues: Insights into α-Glucosidase, α-Amylase,
and Antioxidant Activities. Pharmaceuticals. 2022; 15(12):1576.
https://doi.org/10.3390/ph15121576.

9) Khirallah SM,, Ramadan HMM, El-Deen, IM, El rayess RA. Design,
Synthesis, and Antiproliferative Activities of 1,3-Disubstituted 2-
Thioxoimidazolidin-4-one Derivatives against HepG2 and MCF-7 Cells.
ChemistrySelect. 2023; 8(32). e202301098.
10) Shokeir AA, Awadalla A, Hamam ET, Hussein AM, Mahdi MR, Abosteta
AN, Shahin M, Barakat N, El-Adl M, El-Sherbiny M, Eldesoqui M, AlMadani M,
Ali SK, El-Sherbini ES, Khirallah SM. Human Wharton's jelly-derived
mesenchymal stromal stem cells preconditioned with valproic acid promote cell
migration and reduce renal inflammation in ischemia/reperfusion injury by
activating the AKT/P13K and SDF1/CXCR4 pathways. Arch Biochem Biophys.
2024 Apr 4;755:109985.
11) A. Awadalla, T.A. Elkhooly, A. El-Assmy, E.T. Hamam, M. Ali, A.M. Sena, D.
Shokeir, A.A. Shokeir, R.A. Gabal, S.M. Khirallah, Electrospun nanostructured
heparin conjugated-poly-ε-caprolactone based scaffold promote differentiation of
smooth muscle cells from adipose mesenchymal stem cells, Process Biochem. 143
(2024) 148–162. https://doi.org/https://doi.org/10.1016/j.procbio.2024.04.038.

12) N. Barakat, M.A. Alkhen, Y. Khater, S.M. Khirallah, Effect of Melatonin
and Ginseng on rat testis and sperm quality against cadmium toxicity via
inhibiting oxidative stress and autophagy pathways, J. Trace Elem. Med. Biol.
88 (2025) 127614.
https://doi.org/https://doi.org/10.1016/j.jtemb.2025.127614.
13) Shora HA, El-Deen IM, El-Lithy NM, Abo-Elmatty DM, Khirallah SM.
Growth differentiation factor-15: A marker for diabetic kidney disease in
patients with metabolic-associated fatty liver disease. J Diabetes
Complications. 2025 Apr 7;39(6):109037. doi:
10.1016/j.jdiacomp.2025.109037. Epub ahead of print. PMID: 40233467.

11) Barakat N, Elsharkawy K, Awad A, Khirallah SM. Daxas provides
renoprotective effects in ischemia-reperfusion injury by targeting apoptosis,
Salma Moustafa Moustafa Ahmed Khirallah
5
oxidative stress, and inflammation pathways. Tissue Cell. 2025 May
28;96:102996. doi: 10.1016/j.tice.2025.102996. Epub ahead of print. PMID:
40446760.
15) El-Emshaty HM, Eladle EA, Abdel-Wahab M, Khirallah SM. Potential
role of pentraxin 3 (PTX3) and aldehyde dehydrogenase (ALDH) in liver
cirrhotic patients: predicting and diagnostic impact in hepatocellular
carcinoma (HCC) development. Mol Biol Rep. 2025 Aug 13;52(1):826. doi:
10.1007/s11033-025-10909-1. PMID: 40802153.

16) Hassan A. Shora, Ibrahim M. EL-Deen, Naglaa M. El-Lithy, Dina M.
Abo-Elmatty, Salma M. Khirallah. Cytokeratin 18 and Soluble Cluster of
Differentiation-36: Markers for Nephropathy in Patients with Metabolic
Dysfunction-Associated Fatty Liver Disease. Egyptian Journal of Internal
Medicine. Acceptance 2 November 2025